Single and repeated baclofen treatment attenuates the discriminative stimulus effects of morphine in rats.

@article{Bartoletti2010SingleAR,
  title={Single and repeated baclofen treatment attenuates the discriminative stimulus effects of morphine in rats.},
  author={Maria Bartoletti and Alessia Colantoni and Valentina de Luca and Margherita Gaiardi},
  journal={Pharmacology, biochemistry, and behavior},
  year={2010},
  volume={97 2},
  pages={279-83}
}
The GABA(B) agonists block the rewarding properties of opiates. However, the role of GABA(B) receptors in the discriminative properties of these drugs has received little attention. In this line, the present study was performed to investigate the effects of acute (Experiment 1) and chronic (Experiment 2) pretreatment with baclofen on the discriminative stimulus effects of morphine. Rats were trained to discriminate morphine (5mg/kgi.p.) from saline under a two-lever fixed-ratio schedule of food… CONTINUE READING