Single and multiple input modules in regulatory networks

  title={Single and multiple input modules in regulatory networks},
  author={Arun Siddharth Konagurthu and Arthur M. Lesk},
  journal={Proteins: Structure},
Interactions between transcription factors and target genes form regulatory networks that control target gene expression. Regulatory networks contain canonical motifs, including the feed forward loop (FFL), single input module (SIM), and multiple input module (MIM) (Fig. 1 ). A challenge for network analysis is to identify and enumerate the motifs, required to illuminate their biological significance. Although there is consensus about the definition of the FFL, published definitions of the SIM… 
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