Single- and multiple-dose pharmacokinetic and dose-proportionality study of oxymorphone immediate-release tablets.

@article{Adams2005SingleAM,
  title={Single- and multiple-dose pharmacokinetic and dose-proportionality study of oxymorphone immediate-release tablets.},
  author={Michael P. Adams and Harry Ahdieh},
  journal={Drugs in R&D},
  year={2005},
  volume={6 2},
  pages={91-9}
}
INTRODUCTION Oxymorphone hydrochloride (referred to as oxymorphone), a semisynthetic mu-opioid agonist, is known to produce a more rapid onset of action and greater analgesic potency compared with its parent compound, morphine. Until recently, oxymorphone has been available only in suppository and intravenous formulations. This study examined the pharmacokinetics and dose proportionality of a new immediate-release (IR) tablet formulation of oxymorphone and its metabolites (6-OH-oxymorphone and… CONTINUE READING