Single- and multiple-dose kinetics of estazolam, a triazolo benzodiazepine

@article{Allen2004SingleAM,
  title={Single- and multiple-dose kinetics of estazolam, a triazolo benzodiazepine},
  author={Marcia Divoll Allen and David J Greenblatt and John D. Van Arnold},
  journal={Psychopharmacology},
  year={2004},
  volume={66},
  pages={267-274}
}
The pharmacokinetic properties of estazolam, a triazolo benzodiazepine hypnotic agent, were assessed in a series of healthy volunteers following single and multiple doses. After single oral doses of 2–16 mg, peak plasma concentrations were reached within 6 h. Values of elimination half-life ranged from 8.3–31.2 h (mean 17.0 h) and did not vary significantly with dose. During 3 weeks of therapy, steady-state plasma concentrations increased approximately in proportion to increasing doses, and… 
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