Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer.

@article{Beuten2009SingleAM,
  title={Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer.},
  author={Joke Beuten and Jonathan A. Gelfond and Jennifer L. Franke and Korri S Weldon and Analisa C Crandall and Teresa L. Johnson-Pais and Ian M. Thompson and Robin J. Leach},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2009},
  volume={18 6},
  pages={1869-80}
}
To estimate the prostate cancer risk conferred by individual single nucleotide polymorphisms (SNPs), SNP-SNP interactions, and/or cumulative SNP effects, we evaluated the association between prostate cancer risk and the genetic variants of 12 key genes within the steroid hormone pathway (CYP17, HSD17B3, ESR1, SRD5A2, HSD3B1, HSD3B2, CYP19, CYP1A1, CYP1B1, CYP3A4, CYP27B1, and CYP24A1). A total of 116 tagged SNPs covering the group of genes were analyzed in 2,452 samples (886 cases and 1,566… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Endocrinology of the prostate

  • E Cheng, C Lee, J. Grayhack
  • Prostate diseases. Philadelphia (PA): Saunders…
  • 1993
Highly Influential
17 Excerpts

A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment Cancer Epidemiology, Biomarkers & Prevention Cancer Epidemiol Biomarkers Prev 2009;18(6)

  • XY Lou, GB Chen, L Yan
  • June 2009 1879 on April
  • 2009

Similar Papers

Loading similar papers…