Single- and double-strand photocleavage of DNA by YO, YOYO and TOTO.

@article{kerman1996SingleAD,
  title={Single- and double-strand photocleavage of DNA by YO, YOYO and TOTO.},
  author={Bj{\"o}rn {\AA}kerman and Eimer Tuite},
  journal={Nucleic acids research},
  year={1996},
  volume={24 6},
  pages={
          1080-90
        }
}
Photocleavage of dsDNA by the fluorescent DNA stains oxazole yellow (YO), its dimer YOYO) and the dimer TOTO of thiazole orange (TO) has been investigated as a function of binding ratio. On visible illumination, both YO and YOYO cause single-strand cleavage, with an efficiency that varies with the dye/DNA binding ratio in a manner which can be rationalized in terms of free dye being an inefficient photocleavage reagent and externally bound dye being more efficient than intercalated dye… CONTINUE READING

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