• Corpus ID: 42117849

Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin.

@article{Aberle1996SingleAA,
  title={Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin.},
  author={Hermann Aberle and Hillel Schwartz and Heinz Hoschuetzky and Rolf Kemler},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 3},
  pages={
          1520-6
        }
}
Analysis of the calcium-dependent cell adhesion molecule E-cadherin has led to the identification of catenins, which are necessary for cadherin function. Growing evidence that cadherins and catenins are subjected to genetic alterations in carcinogenesis makes it especially important to understand protein-protein interactions within the cadherin-catenin complex. Here we report the identification and analysis of the alpha-catenin binding site in plakoglobin (gamma-catenin). Using N- and C… 
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