Single amino acid residues in the E- and P-selectin epidermal growth factor domains can determine carbohydrate binding specificity.

@article{Revelle1996SingleAA,
  title={Single amino acid residues in the E- and P-selectin epidermal growth factor domains can determine carbohydrate binding specificity.},
  author={B M Revelle and Donald Scott and Peter J. Beck},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 27},
  pages={16160-70}
}
E-selectin and P-selectin are two closely related vascular cell adhesion proteins. Each selectin has an amino-terminal C-type lectin domain that is thought to possess the carbohydrate binding site that binds the sialylated Lewisx antigen (sLex or CD15s) (Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc). In addition to the sLex carbohydrate, P-selectin binds sulfated proteoglycan, 3-sulfated galactosyl ceramide (sulfatide), and heparin. Both E- and P-selectin have an EGF-like (EGF) domain that is… CONTINUE READING
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