Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence.

@article{Jiang1993SingleAA,
  title={Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence.},
  author={Wen Rui Jiang and Alex Lowe and Stephen T Higgs and Hugh Reid and Ernest Andrew Gould},
  journal={The Journal of general virology},
  year={1993},
  volume={74 ( Pt 5)},
  pages={931-5}
}
Seven mutant viruses were derived from a Scottish strain of louping ill virus using a virus envelope-specific neutralizing monoclonal antibody. None of the mutants was neutralized and immunofluorescence microscopy confirmed that they did not bind to this antibody. Four mutants showed reduced mouse neurovirulence compared with parent virus and two mutants failed to induce protective immune responses in mice challenged with virulent tick-borne encephalitis virus. The mutants with the lowest… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus

M. TRUDEL, J. A. MELERO
Journal of General Virology • 1992

Nucleotide sequence of the envelope glycoprotein of Negishi virus shows very close homology to louping ill virus

H. W. REID, E. A. GOULD
Virology 190, • 1992

Antigenicity of flaviviruses

S.
Archives of Virology Supplementum 1, 137-152. GRITSUN, T. S., LASHKEVICH, • 1990

The envelope protein E of tick - borne encephalitis virus and other flaviviruses : structure , function and evolutionary relationships

F. X. HEINZ, C. W. MANDL, +3 authors C. KUNZ
Archives of Virology Supplementum • 1990
View 1 Excerpt

The envelope protein E of tick-borne

W. TUMA, C. KUNZ
1990

Similar Papers

Loading similar papers…