Single-amino-acid alterations in a highly conserved central region of vesicular stomatitis virus N protein differentially affect the viral nucleocapsid template functions.

@article{Nayak2009SingleaminoacidAI,
  title={Single-amino-acid alterations in a highly conserved central region of vesicular stomatitis virus N protein differentially affect the viral nucleocapsid template functions.},
  author={Debasis Nayak and Debasis Panda and Subash C. Das and Ming Luo and Asit K Pattnaik},
  journal={Journal of virology},
  year={2009},
  volume={83 11},
  pages={
          5525-34
        }
}
The nucleocapsid protein (N) of vesicular stomatitis virus and other rhabdoviruses plays a central role in the assembly and template functions of the viral N-RNA complex. The crystal structure of the viral N-RNA complex suggests that the central region of the N protein interacts with the viral RNA. Sequence alignment of rhabdovirus N proteins revealed several highly conserved regions, one of which spanned residues 282 to 291 (GLSSKSPYSS) in the central region of the molecule. Alanine-scanning… CONTINUE READING

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