Single-agent chemotherapy of brain tumors. A five-year review.

@article{Wilson1976SingleagentCO,
  title={Single-agent chemotherapy of brain tumors. A five-year review.},
  author={Charles Bo Wilson and Philip H. Gutin and E B Boldrey and D Drafts and V. A. Levin and K J Enot},
  journal={Archives of neurology},
  year={1976},
  volume={33 11},
  pages={739-44}
}
Identification of effective single chemotherapeutic agents for brain tumors must precede the rational use of multiple drug combinations. In phase 2 trials beginning in 1968, 158 patients with intrinsic brain tumors (mostly recurrent malignant astrocytomas) were considered evaluable. The larger trials with more effective drugs produced these results: carmustine (BCNU) response rate, 47%, with median duration of nine months; lomustine (CCNU), 44%, with median duration of six months; procarbazine… CONTINUE READING

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