Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.

@article{Burnouf1989SingleAM,
  title={Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.},
  author={Dominique Y Burnouf and Patrice Koehl and Robert P Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 11},
  pages={
          4147-51
        }
}
2-Acetylaminofluorene (AAF), a potent rat liver carcinogen that binds covalently to the C-8 position of guanine residues in DNA, is an effective frameshift mutagen. The mutations are distributed nonrandomly, in that most are located at a few specific DNA sequences (i.e., mutation hot spots). Among these hot spots, the Nar I sequence (GGCGCC) is especially susceptible to the induction of -2 frameshift mutations (GGCGCC----GGCC). Due to the nature of the Nar I sequence, G1G2CG3CC, three different… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS