Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques

@article{Mercado2020SingleShotAV,
  title={Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques},
  author={Noe B. Mercado and R. Zahn and Frank Wegmann and C. Loos and A. Chandrashekar and J. Yu and J. Liu and L. Peter and Katherine McMahan and Lisa H. Tostanoski and Xuan He and D. R. Martinez and L. Rutten and R. Bos and Daniëlle van Manen and J. Vellinga and J. Custers and J. Langedijk and Ted Kwaks and M. J. Bakkers and D. Zuijdgeest and S. R. Huber and C. Atyeo and S. Fischinger and John S. Burke and J. Feldman and B. Hauser and T. Caradonna and Esther A Bondzie and Gabriel Dagotto and Makda S. Gebre and Emily Hoffman and Catherine Jacob-Dolan and Marinela Kirilova and Zhenfeng Li and Zijin Lin and S. Mahrokhian and L. F. Maxfield and Felix Nampanya and Ramya Nityanandam and J. Nkolola and Shivani Patel and John D. Ventura and Kaylee Verrington and Huahua Wan and Laurent Pessaint and Alex Van Ry and Kelvin Blade and Amanda Strasbaugh and Mehtap Cabus and Renita Brown and Anthony Cook and Serge Zouantchangadou and Elyse Teow and H. Andersen and M. Lewis and Yongfei Cai and B. Chen and A. Schmidt and R. K. Reeves and R. Baric and D. Lauffenburger and G. Alter and Paul Stoffels and M. Mammen and J. Hoof and H. Schuitemaker and D. Barouch},
  journal={Nature},
  year={2020},
  volume={586},
  pages={583 - 588}
}
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1–8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in nonhuman primates. 52 rhesus macaques… Expand
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