Background: Though less invasive than open and standard laparoscopic surgery, there are no enough data in the literature regarding evaluation of Single Incision Laparoscopic Surgery (SILS) for diverse colorectal diseases, including malignancy. Lately, we planned to implement this technique in our institution by a prospective study including 20 Egyptian patients. The objective was to master a technique preferred by most patients who are always fascinated by a scarless operation with a short hospital stay. Patients and Methods: For a complete year ending December 2012, 20 patients having different indications for colorectal surgery were enrolled in the study. All were subjected to SILS. Exclusion criteria included: Patients with Body Mass Index (BMI) >35, T4 cancer and recurrent and emergency cases. Results: Patient list included 12 females and 8 males having mean age 50 years (range: 18-70). Median ASA (American Society of Anaesthesiologists) grade was I-II and mean BMI was 31 (range 22-35). The indication for the procedure was 17 malignant and 3 benign lesions. The operative time ranged from 60 to 300 minutes. The period of postoperative hospital stay ranged from 3-15 days. The intraoperative blood loss ranged from was 0-1700ml. Incidence of postoperative wound infection was 5%, a bit higher in rectal procedures. Conversion rate was 15% and the overall mortality rate was 5%. Conclusion: SILS colectomy with or without proctectomy is a feasible and safe procedure for both benign and malignant colorectal diseases.