Single Nucleotide Polymorphisms of the Angiotensin-Converting Enzyme (ACE) Gene Are Associated with Essential Hypertension and Increased ACE Enzyme Levels in Mexican Individuals

@inproceedings{MartnezRodrguez2013SingleNP,
  title={Single Nucleotide Polymorphisms of the Angiotensin-Converting Enzyme (ACE) Gene Are Associated with Essential Hypertension and Increased ACE Enzyme Levels in Mexican Individuals},
  author={Nancy Mart{\'i}nez-Rodr{\'i}guez and Carlos Posadas-Romero and Teresa Villarreal-Molina and Maite Vallejo and Leonardo Del-Valle-Mondrag{\'o}n and Juli{\'a}n Ram{\'i}rez-Bello and Ad{\'a}n Valladares and Miguel Cruz-L{\'o}pez and Gilberto Vargas-Alarc{\'o}n},
  booktitle={PloS one},
  year={2013}
}
AIM To explore the role of the ACE gene polymorphisms in the risk of essential hypertension in Mexican Mestizo individuals and evaluate the correlation between these polymorphisms and the serum ACE levels. METHODS Nine ACE gene polymorphisms were genotyped by 5' exonuclease TaqMan genotyping assays and polymerase chain reaction (PCR) in 239 hypertensive and 371 non- hypertensive Mexican individuals. Haplotypes were constructed after linkage disequilibrium analysis. ACE serum levels were… CONTINUE READING

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