Single Nucleotide Polymorphisms Upstream from the b-Carotene 15 , 15 ’-Monoxygenase Gene Influence Provitamin A Conversion Efficiency in Female Volunteers 1 – 4

@inproceedings{Lietz2011SingleNP,
  title={Single Nucleotide Polymorphisms Upstream from the b-Carotene 15 , 15 ’-Monoxygenase Gene Influence Provitamin A Conversion Efficiency in Female Volunteers 1 – 4},
  author={Georg Lietz and Anthony Oxley and Wing Leung and J. D. Hesketh},
  year={2011}
}
b-Carotene, the most abundant provitamin A carotenoid in the diet, is converted to retinal by b-carotene 15,15’monoxygenase (BCMO1). However, b-carotene absorption and conversion into retinal is extremely variable among individuals, with proportions of low responders to dietary b-carotene as high as 45%. Recently, 2 common nonsynonymous single nucleotide polymorphisms (SNPs) within the BCMO1 coding region (R267S; rs12934922 and A379V; rs7501331) revealed reduced catalytic activity, confirming… CONTINUE READING
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