Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis

Abstract

We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular defects may provide new insight in the pathogenesis of systemic mastocytosis (SM). SNP-A karyotyping was applied to identify recurrent areas of loss of heterozygosity and bidirectional sequencing was performed to evaluate the mutational status of TET2, DNMT3A… (More)
DOI: 10.1371/journal.pone.0043090

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@inproceedings{Traina2012SingleNP, title={Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis}, author={Fabiola Traina and V Visconte and Anna Maria Jankowska and Hideki Makishima and Christine L. O’Keefe and Paul Elson and Yingchun Han and Fred H. Hsieh and Mikkael A. Sekeres and Raghuveer Singh Mali and Matt E. Kalaycio and Alan Eli Lichtin and Anjali S. Advani and Hien K. Duong and Edward A. Copelan and Reuben Kapur and Sara Teresinha Olalla Saad and Jaroslaw Maciejewski and Ram{\'o}n V. Tiu}, booktitle={PloS one}, year={2012} }