Single Na+ channel currents observed in cultured rat muscle cells

@article{Sigworth1980SingleNC,
  title={Single Na+ channel currents observed in cultured rat muscle cells},
  author={Fred J. Sigworth and Erwin Neher},
  journal={Nature},
  year={1980},
  volume={287},
  pages={447-449}
}
The voltage- and time-dependent conductance of membrane Na+ channels is responsible for the propagation of action potentials in nerve and muscle cells. In voltage-step-clamp experiments on neurone preparations containing 104–107 Na+ channels the membrane conductance shows smooth variations in time, but analysis of fluctuations1,2 and other evidence3 suggest that the underlying single-channel conductance changes are stochastic, rapid transitions between ‘closed’ and ‘Open’ states as seen in… 
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