Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

@inproceedings{Narayan2013SingleMC,
  title={Single Molecule Characterization
of the Interactions
between Amyloid-β Peptides and the Membranes of Hippocampal
Cells},
  author={Priyanka Narayan and Kristina A Ganzinger and James McColl and Laura Weimann and Sarah Meehan and Seema S Qamar and John A Carver and Mark R. Wilson and Peter St George-Hyslop and Christopher M. Dobson and David Klenerman},
  booktitle={Journal of the American Chemical Society},
  year={2013}
}
Oligomers of the 40 and 42 residue amyloid-β peptides (Aβ40 and Aβ42) have been implicated in the neuronal damage and impaired cognitive function associated with Alzheimer's disease. However, little is known about the specific mechanisms by which these misfolded species induce such detrimental effects on cells. In this work, we use single-molecule imaging techniques to examine the initial interactions between Aβ monomers and oligomers and the membranes of live cells. This highly sensitive… CONTINUE READING