Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice.

@article{Schroeder2003SingleLC,
  title={Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice.},
  author={Frank C Schroeder and Gunnar Klein and Beate Fiedler and Michaela Bastein and Nicole Schnasse and Anja Hillmer and Sandra Ames and Stepan P Gambaryan and Helmut Drexler and Ulrich Walter and Suzanne M. Lohmann and Kai C. Wollert},
  journal={Cardiovascular research},
  year={2003},
  volume={60 2},
  pages={268-77}
}
OBJECTIVE Calcium entry via the L-type Ca(2+) channel (LTCC) is crucial for excitation-contraction (EC) coupling and activation of Ca(2+)-dependent signal transduction pathways in cardiac myocytes. Both nitric oxide (NO), signaling via cGMP, and acetylcholine, signaling via the muscarinic receptor, have been identified as negative regulators of beta-adrenoreceptor-stimulated LTCC activity in cardiac myocytes. METHODS To examine the potential role of cGMP-dependent protein kinase type I (PKG I… CONTINUE READING

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