Single-Dose Pharmacokinetics of Ro 17-2301 ( AMA-1080 ) , a Monocyclic , B-Lactam , in Humans

@inproceedings{WeidekammSingleDosePO,
  title={Single-Dose Pharmacokinetics of Ro 17-2301 ( AMA-1080 ) , a Monocyclic , B-Lactam , in Humans},
  author={Erhard Weidekamm and Klaus Stoeckel and ' HERMANN-JOSEF EGGER and Walter H. Ziegler and Shuichi Kishimoto and K. Okonogi}
}
Ro 17-2301 (AMA-1080) is a new N-sulfonated monocyclic beta-lactam that is highly active against gram-negative bacteria, especially against Enterobacteriaceae and Haemophilus, Neisseria, and Pseudomonas spp. (Kondo et al., Proc. Int. Congr. Chemother. 13th, Vienna, Austria, p. 56/1-56/5, 1983). The single-dose pharmacokinetics of this compound were studied in six healthy male volunteers who received intravenous infusions of 500, 1,000, and 2,000 mg. A good linear correlation (r2 = 0.99) was… CONTINUE READING

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