Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs

  title={Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs},
  author={Myoung-Seok Kim and Seoung-Ho Ham and Jun-Ho Kim and Ji-Eun Shin and Jin Hui Oh and Tae Won Kim and Hyo-in Yun and Jong-hwan Lim and Beom-su Jang and Jung-Hee Cho},
  booktitle={Toxicological research},
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu- 100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological… CONTINUE READING


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