Single Cells Isolated from Human Sinoatrial Node: Action Potentials and Numerical Reconstruction of Pacemaker Current

@article{Verkerk2007SingleCI,
  title={Single Cells Isolated from Human Sinoatrial Node: Action Potentials and Numerical Reconstruction of Pacemaker Current},
  author={A. O. Verkerk and M.M.G. van Borren and R. J. G. Peters and Eli Broekhuis and K. Y. Lam and Ruben Coronel and J.M.T. de Bakker and H Tan and Ronald Wilders},
  journal={2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
  year={2007},
  pages={904-907}
}
Pacemaker activity of the sinoatrial node has extensively been studied in laboratory animals of various species, but is virtually unexplored in man. Most experimental data have been obtained from rabbit, where the hyper- polarization-activated 'funny' current (If), also known as the 'pacemaker current', plays an important role in diastolic depolarization and thus in setting pacing rate. Recently, we isolated pacemaker cells from excised human sinoatrial node tissue, and recorded action… CONTINUE READING
Highly Cited
This paper has 57 citations. REVIEW CITATIONS
18 Citations
14 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

57 Citations

0102030'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 57 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Current If and its contribution to cardiac pacemaking

  • D. DiFrancesco, D. Noble
  • Neuronal and Cellular Oscillators, J. W. Jacklet…
  • 1989
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…