Single-Cell Transcriptomics Bioinformatics and Computational Challenges

  title={Single-Cell Transcriptomics Bioinformatics and Computational Challenges},
  author={Olivier B. Poirion and Xun Zhu and Travers Ching and Lana X. Garmire},
  booktitle={Front. Genet.},
The emerging single-cell RNA-Seq (scRNA-Seq) technology holds the promise to revolutionize our understanding of diseases and associated biological processes at an unprecedented resolution. It opens the door to reveal intercellular heterogeneity and has been employed to a variety of applications, ranging from characterizing cancer cells subpopulations to elucidating tumor resistance mechanisms. Parallel to improving experimental protocols to deal with technological issues, deriving new… CONTINUE READING
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