Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

@article{Giraddi2018SingleCellTD,
  title={Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development},
  author={Rajshekhar R. Giraddi and C. Chung and R. Heinz and O. Balcioglu and M. Novotny and Christy L Trejo and Christopher Dravis and B. Hagos and Elnaz Mirzaei Mehrabad and L. Rodewald and Jae-Yeon Hwang and C. Fan and R. Lasken and K. Varley and C. Perou and G. Wahl and B. Spike},
  journal={Cell reports},
  year={2018},
  volume={24},
  pages={1653 - 1666.e7}
}
SUMMARY The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We address this significant knowledge gap by generating a single-cell transcriptome atlas encompassing embryonic, postnatal, and adult mouse mammary development. From these data, we map the chronology of transcriptionally and epigenetically distinct cell… Expand
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