Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects.

  title={Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects.},
  author={Xiaoyan Zhang and Sadie L Marjani and Zhaoyang Hu and Sherman Morton Weissman and Xinghua Pan and Shixiu Wu},
  journal={Cancer research},
  volume={76 6},
Advances in genomic technology have enabled the faithful detection and measurement of mutations and the gene expression profile of cancer cells at the single-cell level. Recently, several single-cell sequencing methods have been developed that permit the comprehensive and precise analysis of the cancer-cell genome, transcriptome, and epigenome. The use of these methods to analyze cancer cells has led to a series of unanticipated discoveries, such as the high heterogeneity and stochastic changes… 

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