Single Cell RNA Sequencing of Rare Immune Cell Populations

  title={Single Cell RNA Sequencing of Rare Immune Cell Populations},
  author={Akira Nguyen and Weng Hua Khoo and Imogen Moran and Peter I. Croucher and Tri Giang Phan},
  journal={Frontiers in Immunology},
Single-cell RNA sequencing (scRNA-Seq) is transforming our ability to characterize cells, particularly rare cells that are often overlooked in bulk population analytical approaches. This has lead to the discovery of new cell types and cellular states that echo the underlying heterogeneity and plasticity in the immune system. Technologies for the capture, sequencing, and bioinformatic analysis of single cells are rapidly improving, and scRNA-Seq is now becoming much more accessible to non… 

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