Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

@inproceedings{Ting2014SingleCellRS,
  title={Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells},
  author={David T. Ting and Ben S. Wittner and Matteo Ligorio and Nicole Vincent Jordan and Ajay M. Shah and David T. Miyamoto and Nicola Aceto and Francesca Bersani and Brian W. Brannigan and Kristina Xega and Jordan C Ciciliano and Huili Zhu and Olivia Mackenzie and Julie Trautwein and Kshitij Arora and Mohammad Shahid and Haley L. Ellis and Na Qu and Nabeel Bardeesy and Miguel N. Rivera and Vikram Deshpande and Cristina R Ferrone and Ravi Kapur and Sridhar Ramaswamy and Toshi Shioda and Mehmet Toner and S. Maheswaran and Daniel A. Haber},
  booktitle={Cell reports},
  year={2014}
}
Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define their composition, we compared genome-wide expression profiles of CTCs with matched primary tumors in a mouse model of pancreatic cancer, isolating individual CTCs using epitope-independent microfluidic capture, followed by single-cell RNA sequencing. CTCs clustered separately from primary tumors and tumor-derived cell lines, showing low… CONTINUE READING
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