Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.

  title={Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.},
  author={Jaehoon Shin and Daniel A. Berg and Yunhua Zhu and Joseph Y. Shin and Juan Song and Michael Anthony Bonaguidi and Grigori Enikolopov and David W. Nauen and Kimberly M. Christian and Guoli Ming and Hongjun Song},
  journal={Cell stem cell},
  volume={17 3},
Somatic stem cells contribute to tissue ontogenesis, homeostasis, and regeneration through sequential processes. Systematic molecular analysis of stem cell behavior is challenging because classic approaches cannot resolve cellular heterogeneity or capture developmental dynamics. Here we provide a comprehensive resource of single-cell transcriptomes of adult hippocampal quiescent neural stem cells (qNSCs) and their immediate progeny. We further developed Waterfall, a bioinformatic pipeline, to… CONTINUE READING
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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

  • C. Trapnell, D. Cacchiarelli, +7 authors J. L. Rinn
  • Nat. Biotechnol
  • 2014
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