Single-Cell Multiomics: Multiple Measurements from Single Cells

  title={Single-Cell Multiomics: Multiple Measurements from Single Cells},
  author={Iain Macaulay and Chris P. Ponting and Thierry Voet},
  booktitle={Trends in genetics : TIG},
Single-cell sequencing provides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples. Sequencing of one molecular type (RNA, methylated DNA or open chromatin) in a single cell, furthermore, provides insights into the cell's phenotype and links to its genotype. Nevertheless, only by taking measurements of these phenotypes and genotypes from the same single cells can such inferences be made unambiguously. In this review, we survey the first experimental… CONTINUE READING