Single-Cell Mass Spectrometry Approaches to Explore Cellular Heterogeneity.

  title={Single-Cell Mass Spectrometry Approaches to Explore Cellular Heterogeneity.},
  author={Linwen Zhang and A. Vertes},
  journal={Angewandte Chemie},
  volume={57 17},
  • Linwen Zhang, A. Vertes
  • Published 2018
  • Chemistry, Medicine
  • Angewandte Chemie
  • Compositional diversity is a fundamental property in cell populations. Single-cell analysis promises new insight into this cellular heterogeneity on the genomic, transcriptomic, proteomic, and metabolomic levels. Mass spectrometry (MS) is a label-free technique that enables the multiplexed analysis of proteins, peptides, lipids, and metabolites in individual cells. The abundances of these molecular classes are correlated with the physiological states and environmental responses of the cells. In… CONTINUE READING
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