Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.

  title={Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.},
  author={Maarja Andaloussi M{\"a}e and Liqun He and Sofia Nordling and Elisa Vazquez-Liebanas and Khayrun Nahar and Bongnam Jung and Xidan Li and Bryan C. Tan and Juat Chin Foo and Amaury Cazenave-Gassiot and Markus R. Wenk and Yvette Zarb and Barbara Lavina and Susan E. Quaggin and Marie Jeansson and Chengua Gu and David L. Silver and Michael Vanlandewijck and Eugene C. Butcher and Annika Keller and Christer Betsholtz},
  journal={Circulation Research},
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair. Loss of pericytes has been described in several brain disorders, and genetically induced pericyte deficiency in the brain leads to increased macromolecular leakage across the blood-brain barrier (BBB). However, the molecular details of the endothelial response to pericyte deficiency remain elusive. Objective: To map the transcriptional changes in brain… 

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