Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.

@article{Song2017SingleCellAS,
  title={Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.},
  author={Yan Song and Olga B. Botvinnik and Michael T. Lovci and Boyko Kakaradov and Patrick P. Liu and Jia Le Xu and Gene W. Yeo},
  journal={Molecular cell},
  year={2017},
  volume={67 1},
  pages={
          148-161.e5
        }
}
Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in multicellular life. Although AS variation has been observed among single cells, little is known about the biological or evolutionary significance of such variation. We developed Expedition, a computational framework consisting of outrigger, a de novo splice graph transversal algorithm to detect AS; anchor, a Bayesian approach to assign modalities; and bonvoyage, a visualization tool using non-negative… CONTINUE READING
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