Single‐nucleotide polymorphism, rs1799941 in the Sex Hormone‐Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study

@article{Svartberg2014SinglenucleotidePR,
  title={Single‐nucleotide polymorphism, rs1799941 in the Sex Hormone‐Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Troms{\o} Study},
  author={Johan Svartberg and Henrik Schirmer and Tom Wilsgaard and Ellisiv B. Mathiesen and Inger Nj{\o}lstad and Maja-Lisa L{\o}chen and Rolf Jorde},
  journal={Andrology},
  year={2014},
  volume={2}
}
Low testosterone levels are associated with metabolic and cardiovascular disease risk factor, and have been shown to predict type 2 diabetes mellitus (T2DM), myocardial infarction (MI) and all‐cause mortality. It is not known if these associations are causal or not. Recently, it has been shown that the serum testosterone levels are associated with single‐nucleotide polymorphisms (SNPs), and we therefore studied the associations between one of these SNPs, rs1799941 on the Sex Hormone‐Binding… 
Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates.
TLDR
Circulating SHBG is strongly associated with systemic metabolism and predictive for insulin resistance and diabetes, and the weaker causal estimates suggest that the observational associations are partly confounded rather than conferred directly via circulating SHBG.
The role of sex hormone-binding globulin (SHBG), testosterone, and other sex steroids, on the development of type 2 diabetes in a cohort of community-dwelling middle-aged to elderly men
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In men, low TT, but not SHBG and other sex steroids, best predicts the development of T2D after adjustment for confounders.
Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus.
TLDR
The association of SHBG with mortality in men with T2DM is novel and whether SHBG acts via regulation of testosterone, has intrinsic biological roles, or is a marker of poor health requires further study.
Vitamin D and Biomarkers of Sex Steroid Hormones Are Non-Linearly and Inversely Related to All-Cause Mortality: Results from NHANES III
TLDR
Vitamin D and sex steroid hormones, but not sex hormone binding globulin, may be inversely and non-linearly related to all-cause mortality among adult men, after adjustment for baseline demographic, socioeconomic, lifestyle and clinical characteristics.
Distinction of hypertriglyceridemic waist phenotype from simple abdominal obesity: interaction with sex hormone-binding globulin levels to confer high coronary risk
TLDR
HtgW phenotype distinguishes itself from the (virtually neutral) simple abdominal obesity in independently conferring high CHD risk when elevated or reduced SHBG levels interact, and underlying operation of Lp(a) aggregation is suggested.
SHBG Gene Polymorphism (rs1799941) Associates with Metabolic Syndrome in Children and Adolescents
TLDR
The significant association between rs1799941 and MetS in children is not contingent on any single CM trait, and the presence of MetS may abrogate effect of rs 1799941 polymorphism on SHBG levels in children.
Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males
TLDR
The rs1799941 of the SHBG gene can partially determine the presence of obesity-related hypogonadism in young non-diabetic males and whether these subjects have normal FT HG.
Association of rs6259 polymorphism with SHBG levels and Poly Cystic Ovary Syndrome in Indian population: a case control study
TLDR
Significant difference in SHBG levels of PCOS and control group highlights the potential of SHBG as a biomarker for PCOS, however, no significant difference in genotype distribution betweenPCOS and controls provided an insight that rs6259 polymorphism is not associated with the risk of PCos and SH BG levels.
Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?
TLDR
The results suggest that SHBG is a good early marker for metabolic dysregulation in MS, considering its strength of association and significance is comparable to, or better than, those of MS criteria.
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