Single‐cell RNA‐seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63

  title={Single‐cell RNA‐seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63},
  author={N. Tanaka and S. Katayama and A. Reddy and K. Nishimura and N. Niwa and Hiroshi Hongo and Koichiro Ogihara and T. Kosaka and R. Mizuno and E. Kikuchi and Shuji Mikami and Ayako Miyakawa and E. Arenas and J. Kere and M. Oya and P. Uhl{\'e}n},
  journal={Cancer Medicine},
  pages={6193 - 6204}
  • N. Tanaka, S. Katayama, +13 authors P. Uhlén
  • Published 2018
  • Biology, Medicine
  • Cancer Medicine
  • Cancers acquire resistance to systemic treatment with platinum‐based chemotherapy (eg, cisplatin [CDDP]) as a result of a dynamic intratumoral heterogeneity (ITH) and clonal repopulation. However, little is known about the influence of chemotherapy on ITH at the single‐cell level. Here, mapping the transcriptome of cancers treated with CDDP by scRNA‐seq, we uncovered a novel gene, COX7B, associated with platinum‐resistance, and surrogate marker, CD63. Knockdown of COX7B in cancer cells… CONTINUE READING
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