Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17β‐Estradiol

  title={Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17β‐Estradiol},
  author={Thomas M. Price and K. L. Blauer and M. Hansen and F. Stanczyk and R. Lobo and G. W. Bates},
  journal={Obstetrical & Gynecological Survey},
  • Thomas M. Price, K. L. Blauer, +3 authors G. W. Bates
  • Published 1997
  • Medicine
  • Obstetrical & Gynecological Survey
  • Objective To investigate the pharmacokinetic profiles of different doses of micronized 17β-estradiol administered by oral or sublingual routes. Methods Single doses of micronized 17β-estradiol were administered orally (1 mg, 0.5 mg) or sublingually (1 mg, 0.5 mg, 0.25 mg) to six postmenopausal women in a randomized clinical trial. We calculated pharmacokinetic parameters for estradiol (E2) and estrone (E1) of maximum serum concentration, time to maximum serum concentration, terminal half-life… CONTINUE READING
    63 Citations

    Topics from this paper

    Pharmacology of estrogens and progestogens: influence of different routes of administration
    • H. Kuhl
    • Medicine
    • Climacteric : the journal of the International Menopause Society
    • 2005
    • 438
    • PDF


    Biologic effects of transdermal estradiol.
    • 258
    Comparison of transdermal and oral estrogen-progestin replacement therapy: effects on serum lipids and lipoproteins.
    • 181
    Clinical experience with a seven-day estradiol transdermal system for estrogen replacement therapy.
    • S. F. Gordon
    • Medicine
    • American journal of obstetrics and gynecology
    • 1995
    • 55