Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17β‐Estradiol

@article{Price1997SingleDosePO,
  title={Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17$\beta$‐Estradiol},
  author={Thomas M Price and Keith L. Blauer and M. D. Hansen and Frank Z. Stanczyk and Rogerio A. Lobo and G. William Bates},
  journal={Obstetrical \& Gynecological Survey},
  year={1997},
  volume={89},
  pages={340–345}
}
Objective To investigate the pharmacokinetic profiles of different doses of micronized 17β-estradiol administered by oral or sublingual routes. Methods Single doses of micronized 17β-estradiol were administered orally (1 mg, 0.5 mg) or sublingually (1 mg, 0.5 mg, 0.25 mg) to six postmenopausal women in a randomized clinical trial. We calculated pharmacokinetic parameters for estradiol (E2) and estrone (E1) of maximum serum concentration, time to maximum serum concentration, terminal half-life… Expand
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SUBLINGUAL MUCOSA AS A ROUTE FOR SYSTEMIC DRUG DELIVERY
Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a useful when rapid onset of action is desired with better patient… Expand
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