Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17β‐Estradiol

  title={Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17$\beta$‐Estradiol},
  author={Thomas M Price and Keith L. Blauer and M. D. Hansen and Frank Z. Stanczyk and Rogerio A. Lobo and George W. Bates},
  journal={Obstetrical \& Gynecological Survey},

Pharmacokinetics of Sublingual vs. Oral Estradiol in Transgender Women.

Pharmacokinetics of Estradiol Valerate 2mg + Dienogest 2mg (Climodien® 2/2) after Single and Repeated Oral Administration in Healthy Postmenopausal Women

Estradiol may accumulate in plasma during multiple- drug administration with Climodien® 2/2 more than predicted from single-dose results, however, dienogest kinetics after multiple-drug administration were as predicted fromSingle- dose results.

Comparative effects of oral conjugated equine estrogens and micronized 17&bgr;-estradiol on breast proliferation: a retrospective analysis

It is suggested that standard doses of CEE may result in less estrogen-induced epithelial proliferation in the breast compared with E2, and breast epithelial expression of progesterone receptor, a widely used marker of estrogen receptor activity, and endometrial thickness showed similar increases after treatment with CEE.

Pharmacology of estrogens and progestogens: influence of different routes of administration

  • H. Kuhl
  • Medicine, Biology
    Climacteric : the journal of the International Menopause Society
  • 2005
This review comprises the pharmacokinetics and pharmacodynamics of natural and synthetic estrogens and progestogens used in contraception and therapy, with special consideration of hormone

Sublingual Tablets and the Benefits of the Sublingual Route of Administration

Sublingual tablets or any sublingual dosage form can be used to achieve a rapid onset of action, better patient compliance and increased bioavailability as drugs administered sublingually tend to have better bioavailability which correlates to dose reduction when compared to conventional oral tablets.

Sublingual Route of Drug Delivery System: A Review

This review highlights the different sublingual dosage forms, factors affecting theSublingual absorption, advantages, various in vitro and in vivo evaluation parameters and commercially available sublingUAL dosage forms.



Pharmacokinetics of estradiol, free and total estrone, in young women following single intravenous and oral administration of 17 beta-estradiol.

The purpose of the study was to determine the absolute bioavailability of orally administered E2 in a larger group of women and to assess the inter- and intraindividual variability of basic pharmacokinetic parameters of E2 and metabolically derived E1.

Biologic effects of transdermal estradiol

Pharmacokinetics of oral 17 beta-estradiol.

The pharmacokinetics of oral 17 beta-estradiol (E2) were evaluated and smoking enhances the hepatic metabolism of oral estrogen and results primarily in a lower unbound E2 level.

Comparison of transdermal to oral estradiol administration on hormonal and hepatic parameters in women with premature ovarian failure.

Both estrogen replacement regimens provided near-normal serum estradiol profiles, however, despite the relatively high doses necessary to mimic a hormonally normal cycle, the transdermal route did not significantly alter the hepatic parameters studied, suggesting that this route of administration may have less adverse hepatic effects.

Clinical experience with a seven-day estradiol transdermal system for estrogen replacement therapy.

  • S. Gordon
  • Medicine, Biology
    American journal of obstetrics and gynecology
  • 1995