Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17β‐Estradiol

@article{Price1997SingleDosePO,
  title={Single‐Dose Pharmacokinetics of Sublingual Versus Oral Administration of Micronized 17β‐Estradiol},
  author={Thomas M. Price and K. L. Blauer and M. Hansen and F. Stanczyk and R. Lobo and G. W. Bates},
  journal={Obstetrical & Gynecological Survey},
  year={1997},
  volume={89},
  pages={340–345}
}
  • Thomas M. Price, K. L. Blauer, +3 authors G. W. Bates
  • Published 1997
  • Medicine
  • Obstetrical & Gynecological Survey
  • Objective To investigate the pharmacokinetic profiles of different doses of micronized 17β-estradiol administered by oral or sublingual routes. Methods Single doses of micronized 17β-estradiol were administered orally (1 mg, 0.5 mg) or sublingually (1 mg, 0.5 mg, 0.25 mg) to six postmenopausal women in a randomized clinical trial. We calculated pharmacokinetic parameters for estradiol (E2) and estrone (E1) of maximum serum concentration, time to maximum serum concentration, terminal half-life… CONTINUE READING
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