Single‐Dose Kinetics and Bioavailability of Ketobemidone

  title={Single‐Dose Kinetics and Bioavailability of Ketobemidone},
  author={P. Anderson and S. Arn{\'e}r and U. G. Bondesson and Lars O. Bor{\'e}us and Per Hartvig},
  journal={Acta Anaesthesiologica Scandinavica},
The single‐dose kinetics and the oral and rectal bioavailability of ketobemidone have been studied in patients after surgery. Plasma concentrations were determined following intravenous administration of Ketogin® 2 ml, containing ketobemidone chloride 10 mg and the spasmolytic substance N, N‐dimethyl‐3, 3‐diphenyl‐l‐methylallylamine chloride 50 mg and following oral or rectal administration of Ketogin. Ketobemidone was analyzed by gas chromatography‐mass spectrometry using a deuterated internal… 
The pharmacokinetics of ketobemidone in critically ill patients.
There was no correlation between the elimination of ketobemidone in critically ill patients and plasma C-reactive protein, white blood count or plasma albumin concentrations, but there was a wide variation in the different pharmacokinetic parameters among patients.
Bioavailability and analgesic effect of sustained release cetobemidone capsules in cancer patients with chronic pain of malignant origin.
Ever since its introduction in 1952, Ketogan has consisted of a combination of the opioid cetobemidone and a spasmolytic drug, A29, in the ratio of 1:5. Its main limitations are the relatively short
Pharmacokinetic and pharmacodynamic aspects on opioid administration, morphine and ketobemidone, in the pediatric population
The best analgesic for the patient is the one that will effectively decrease pain to a minimum or acceptable pain levels, with as little side effect as possible and without patient disagreement upon administration.
Analgesic effect and bioavailability of oral ketogan given as tablets or mixture to patients with chronic pain of malignant origin.
Thirteen cancer patients with moderate to severe chronic pain of malignant origin on treatment with Ketogan tablets were included in an open non-randomized cross-over study comparing the analgesic
The pharmacokinetics of ketobemidone are not affected by CYP2D6 or CYP2C19 phenotype
The results indicate that the metabolism of ketobemidone is not dependent on CYP 2D6 or CYP2C19, and PMs of debrisoquine or mephenytoin, as well as patients who are concomitantly treated with inhibitors of CYP1D6 and CYP3D6, are not expected to be at higher risk of adverse effects.
Pharmacokinetics after a single intravenous dose of the opioid ketobemidone in neonates
The aim of this clinical trial was to explore the pharmacokinetics of ketobemidone in neonates.
Pharmacokinetics after an intravenous single dose of the opioid ketobemidone in children
This clinical trial was to explore the pharmacokinetics of ketobemidone in children because these properties have not been reported previously.


Rectal bioavailability of lidocaine in man: Partial avoidance of “first‐pass” metabolism
This investigation indicates that in principle it is possible to avoid, at least partly, drug loss caused by “first‐pass” metabolism by giving the drug rectally, and that oral and rectal bioavailability of lidocaine is reproducible in individuals.
The disposition of morphine in surgical patients
The studies demonstrate the applicability and specificity of the radioimmunoassay for morphine and suggest that serum levels of morphine may be a useful and objective indicator of its pharmacologic activity.
Morphine metabolism in man
Morphine metabolism was studied in 6 normal men at weekly intervals after intravenous, intramuscular, subcutaneous, and oral administration, finding n‐demethylation of morphine is greater after oral than after parenteral administration.
The analgesic properties and addiction liability of ketobemidone and morphine.
Only in Germany, where the sale of the drug was unrestricted until 1953, has there been a significant number of addicts and there are reports on 20 cases in Germany either of addiction or of misuse.
Use of human fetal ileum for evaluation of smooth muscle effects of narcotic analgesics.
  • L. Boréus
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    European journal of pharmacology
  • 1971
Synthetic substances with morphine-like effect: clinical experience; potency, side-effects, addiction liability.
A review of effects in man of morphine-like drugs which have been brought under international narcotics control is presented in the form of individual monographs. These are based on controlled
Morphine mctabolism in man
  • Clin. Pharmacol. Ther
  • 1974