Single‐Dose Kinetics and Bioavailability of Ketobemidone

@article{Anderson1982SingleDoseKA,
  title={Single‐Dose Kinetics and Bioavailability of Ketobemidone},
  author={P. Anderson and S. Arn{\'e}r and U. G. Bondesson and Lars O. Bor{\'e}us and Per Hartvig},
  journal={Acta Anaesthesiologica Scandinavica},
  year={1982},
  volume={26}
}
The single‐dose kinetics and the oral and rectal bioavailability of ketobemidone have been studied in patients after surgery. Plasma concentrations were determined following intravenous administration of Ketogin® 2 ml, containing ketobemidone chloride 10 mg and the spasmolytic substance N, N‐dimethyl‐3, 3‐diphenyl‐l‐methylallylamine chloride 50 mg and following oral or rectal administration of Ketogin. Ketobemidone was analyzed by gas chromatography‐mass spectrometry using a deuterated internal… 
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