Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial Genomes

@article{Macaulay2005SingleRC,
  title={Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial Genomes},
  author={V. Macaulay and Catherine Hill and A. Achilli and C. Rengo and Douglas J. Clarke and William Meehan and J. Blackburn and O. Semino and R. Scozzari and F. Cruciani and A. Taha and Norazila Kassim Shaari and Joseph Maripa Raja and P. Ismail and Z. Zainuddin and W. Goodwin and D. Bulbeck and H. Bandelt and S. Oppenheimer and A. Torroni and M. Richards},
  journal={Science},
  year={2005},
  volume={308},
  pages={1034 - 1036}
}
A recent dispersal of modern humans out of Africa is now widely accepted, but the routes taken across Eurasia are still disputed. We show that mitochondrial DNA variation in isolated “relict” populations in southeast Asia supports the view that there was only a single dispersal from Africa, most likely via a southern coastal route, through India and onward into southeast Asia and Australasia. There was an early offshoot, leading ultimately to the settlement of the Near East and Europe, but the… Expand

Topics from this paper

Reconstructing Indian-Australian phylogenetic link
TLDR
The results showing a shared mtDNA lineage between Indians and Australian Aborigines provides direct genetic evidence of an early colonization of Australia through south Asia, following the "southern route". Expand
Carriers of mitochondrial DNA macrohaplogroup R colonized Eurasia and Australasia from a southeast Asia core area
TLDR
Coeval independently dispersals around 50 kya of the West Asia haplogroup U and the Wallacea haplogroups P points to a halfway core area in southeast Asia as the most probable centre of expansion of macrohaplogroup R, what fits in the phylogeographic pattern of its ancestor, macrohaPLogroup N, for which a northern route and a southeast Asian origin has been already proposed. Expand
GENETIC CONTINUITY OF ANATOMICALLY MODERN HUMAN BETWEEN INDIA AND ISLAND SOUTHEAST ASIA ISEA: LAST GLACIAL DISPERSAL OF MTDNA LINEAGE N22
ABSTARCT: Our complete sequencing of 220 mtDNA genomes from t he Savara and Porja of east coastal India reveals about 25 per cent genomes belongs to European macro haplogroup N. For the first time weExpand
The Arabian cradle: mitochondrial relicts of the first steps along the southern route out of Africa.
TLDR
Analysis of three minor west-Eurasian haplogroups shows that they have a relict distribution that suggests an ancient ancestry within the Arabian Peninsula, and they most likely spread from the Gulf Oasis region toward the Near East and Europe during the pluvial period 55-24 ka ago. Expand
Over the sands and far away: Interpreting an Iberian mitochondrial lineage with ancient Western African origins
There is an ongoing effort to characterize the genetic links between Africa and Europe, mostly using lineages and haplotypes that are specific to one continent but had an ancient origin in the other.Expand
Early modern human dispersal from Africa: genomic evidence for multiple waves of migration
TLDR
It is concluded that the hypothesis of a single major human dispersal from Africa appears hardly compatible with the observed historical and geographical patterns of genome diversity and that Australo-Melanesian populations seem still to retain a genomic signature of a more ancient divergence from Africa. Expand
The mtDNA Legacy of the Levantine Early Upper Palaeolithic in Africa
TLDR
The early Upper Palaeolithic population(s) carrying M1 and U6 did not return to Africa along the southern coastal route of the “out of Africa” exit, but from the Mediterranean area; and the North African Dabban and European Aurignacian industries derived from a common Levantine source. Expand
A mitochondrial stratigraphy for island southeast Asia.
TLDR
It is demonstrated that mitochondrial DNA diversity in the region is extremely high and includes a large number of indigenous clades, suggesting that, if an agriculturalist migration did take place in ISEA, it was demographically minor, at least with regard to the involvement of women. Expand
Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia
TLDR
A new and more conciliatory model is constructed to explain the history of modern humans out of Africa by reanalyzing the phylogeography and respective ages of mtDNA haplogroups belonging to macrohaplogroup M in different regions of Eurasia and Australasia. Expand
Out of Africa and into Asia: Fossil and genetic evidence on modern human origins and dispersals
Abstract Genetic and fossil evidence has accumulated in support of an African origin for modern humans. Despite this consensus, several questions remain with regard to the mode and timing ofExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa
TLDR
M is rendered the first genetic indicator for the hypothesized exit route from Africa through eastern Africa/western India, possibly the only successful early dispersal event of modern humans out of Africa. Expand
Major genomic mitochondrial lineages delineate early human expansions
TLDR
The relative relationships among the 42 human lineages are shown and more accurate temporal calibrations are presented than have been previously possible to give new perspectives as how modern humans spread in the Old World. Expand
Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
TLDR
The mitochondrial genome data indicate that Australia was colonized between 40 and 70 thousand years ago, either by a single migration from a heterogeneous source population or by multiple movements of smaller groups occurring over a period of time. Expand
Mitochondrial footprints of human expansions in Africa.
TLDR
Eurasian sequences are derived from essentially one sequence within this ancient cluster, even though a diverse mitochondrial pool was present in Africa at the time. Expand
Multiple dispersals and modern human origins
TLDR
There is no clear rubicon of modern Homo sapiens, and that multiple dispersals occurred from a morphologically variable population in Africa, so pre‐existing African diversity is crucial to the way human diversity developed outside Africa. Expand
The genetic origins of the Andaman Islanders.
TLDR
The results demonstrate that Victorian anthropological collections can be used to study extinct, or seriously admixed populations, to provide new data about early human origins. Expand
Tracing European founder lineages in the Near Eastern mtDNA pool.
TLDR
There has been substantial back-migration into the Near East, there was a founder effect or bottleneck associated with the Last Glacial Maximum, 20,000 years ago, and a way to account for multiple dispersals of common sequence types is suggested. Expand
Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences.
TLDR
This East Asian mtDNA phylogeny can henceforth serve as a solid basis for phylogeographic analyses of mtDNAs, as well as for studies of mitochondrial diseases in East and Southeast Asia. Expand
Geography predicts neutral genetic diversity of human populations
TLDR
It is proposed that the ancestors of all modern humans originated in East Africa and that, around 100,000 years ago, some modern humans left the African continent and subsequently colonised the entire world, displacing previously established human species such as Neanderthals in Europe. Expand
Mitochondrial genome variation in eastern Asia and the peopling of Japan.
TLDR
Population-based comparisons confirmed that present-day Japanese have their closest genetic affinity to northern Asian populations, especially to Koreans, which finding is congruent with the proposed Continental gene flow to Japan after the Yayoi period. Expand
...
1
2
3
4
...