Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity.

@article{Mori2007Singar1AN,
  title={Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity.},
  author={Tatsuya Mori and Tomoe Wada and Toshinori Suzuki and Yoshitsugu Kubota and Naoyuki Inagaki},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 27},
  pages={
          19884-93
        }
}
Although neuronal functions depend on their robust polarity, the mechanisms that ensure generation and maintenance of only a single axon remain poorly understood. Using highly sensitive two-dimensional electrophoresis-based proteomics, we identified here a novel protein, single axon-related (singar)1/KIAA0871/RPIPx/RUFY3, which contains a RUN domain and is predominantly expressed in the brain. Singar1 expression became up-regulated during polarization of cultured hippocampal neurons and… CONTINUE READING

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