Sindbis virus membrane fusion is mediated by reduction of glycoprotein disulfide bridges at the cell surface.

@article{Abell1993SindbisVM,
  title={Sindbis virus membrane fusion is mediated by reduction of glycoprotein disulfide bridges at the cell surface.},
  author={B A Abell and Dennis T. Brown},
  journal={Journal of virology},
  year={1993},
  volume={67 9},
  pages={5496-501}
}
We have examined the role of thiol-disulfide exchange reactions during the penetration of cells by Sindbis virus. The protein-protein association that form the rigid icosahedral lattice of the Sindbis virus envelope have been shown to be stabilized by disulfide bridges, and reduction of these critical disulfide bridges during cell penetration may be the mechanism by which the rigid protein lattice is disrupted prior to fusion (R. Anthony and D. T. Brown, J. Virol. 65:1187-1194, 1991; R. Anthony… CONTINUE READING