Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs.

Abstract

Since the recovery of infectious RNA transcripts from full-length cDNA clones, alphavirus genome RNAs have been engineered to allow expression of heterologous RNAs and proteins. The highest levels of expression of heterologous products are achieved when the viral structural genes are replaced by the heterologous coding sequences. Such recombinant RNAs are… (More)

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@article{Bredenbeek1993SindbisVE, title={Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs.}, author={Peter J. Bredenbeek and Ilya Frolov and Charles M. Rice and S. Schlesinger}, journal={Journal of virology}, year={1993}, volume={67 11}, pages={6439-46} }