Sindbis viral-mediated expression of Ca2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation.

@article{Okada2001SindbisVE,
  title={Sindbis viral-mediated expression of Ca2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation.},
  author={Toshiyuki Okada and Nobuaki Yamada and Wataru Kakegawa and Keisuke Tsuzuki and Masahito Kawamura and Hiroyuki Nawa and Masamitsu Iino and Seiji Ozawa},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 8},
  pages={1635-43}
}
Gene manipulation in order to artificially express a particular gene in neurons in the central nervous system is a powerful tool for the analysis of brain function. Sindbis viral vectors have been developed to express high levels of foreign genes in postmitotic brain neurons with little transfection of glial cells. In this study, we expressed the gene encoding the unedited GluR2 (GluR-B) subunit of the AMPA-type glutamate receptor that forms inwardly rectifying and Ca2+-permeable channels, in… CONTINUE READING
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