Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.

@article{Makino2006Sin1BT,
  title={Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.},
  author={Chieko Makino and Yuji Sano and Toshie Shinagawa and Jonathan B. A. Millar and Shunsuke Ishii},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2006},
  volume={11 11},
  pages={1239-51}
}
Yeast Sin1 binds to the Sty1 kinase, a member of the stress-activated kinases (SAPKs), and is required for stress-induced phosphorylation and activation of the transcription factor Atf1, a homolog of the vertebrate-activating transcription factor-2 (ATF-2). Here we report that mammalian Sin1 plays an important role in the SAPK signaling pathway by binding to both ATF-2 and p38. In response to stress, ATF-2, a member of the ATF/cAMP response element-binding protein family, is phosphorylated by… CONTINUE READING