Sin: good or bad? A T lymphocyte perspective.

@article{Alexandropoulos2003SinGO,
  title={Sin: good or bad? A T lymphocyte perspective.},
  author={Konstantina Alexandropoulos and Laura T. Donlin and Luzhou Xing and Adam G. Regelmann},
  journal={Immunological reviews},
  year={2003},
  volume={192},
  pages={181-95}
}
Stimulation of T cells through their antigen receptor induces a multitude of signaling networks that regulate T cell activation in the form of cytokine production and T cell proliferation. Multiple signal integration sites exist along these pathways in the form of multiprotein signaling complexes, the formation of which is facilitated by adapter and scaffold molecules. In recent years a number of adapter and scaffold molecules have been described in T cells and shown to play an integral part in… CONTINUE READING

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