Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients.

@article{Manfredini2010SimvastatinTP,
  title={Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients.},
  author={Vanusa Manfredini and Giovana Brondani Biancini and Camila Simioni Vanzin and Anna Maria Ribeiro Dal Vesco and Franciele Cipriani and Lidiana Biasi and Roberta Trem{\'e}a and Marion Deon and Maria do Carmo Ruaro Peralba and Moacir Wajner and Carmen Regla Vargas},
  journal={Cell biochemistry and function},
  year={2010},
  volume={28 5},
  pages={360-6}
}
Type 2 diabetes (T2D) is associated with increased oxidative stress as indicated by elevated levels of lipid peroxidation and protein oxidation products. Since reactive oxygen species (ROS) can cause damage to biological macromolecules including DNA, this study investigated oxidative damage to DNA using the alkaline (pH > 13) comet assay in peripheral whole blood leukocytes sampled from 15 dyslipidemic T2D patients treated with simvastatin (20 mg/day), 15 dyslipidemic T2D patients not treated… CONTINUE READING
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