Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.

@article{Haack2014SimvastatinTA,
  title={Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.},
  author={Karla K. V. Haack and Noah J Marcus and Rodrigo Del Rio and Irving H. Zucker and Harold D Schultz},
  journal={Hypertension},
  year={2014},
  volume={63 5},
  pages={1041-9}
}
Cheyne-Stokes respiration and cardiac arrhythmias are associated with increased morbidity and mortality in patients with chronic heart failure (CHF). Enhanced carotid body chemoreflex (CBC) sensitivity is associated with these abnormalities in CHF. Reduced carotid body (CB) nitric oxide and nitric oxide synthase (NOS) levels play an important role in the enhanced CBC. In other disease models, Simvastatin (statin) treatment increases endothelial NOS, in part, by increasing Krüppel-like Factor 2… CONTINUE READING
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