Simvastatin represses translocation of Pseudomonas aeruginosa across Madin-Darby canine kidney cell monolayers.

@article{Shibata2012SimvastatinRT,
  title={Simvastatin represses translocation of Pseudomonas aeruginosa across Madin-Darby canine kidney cell monolayers.},
  author={Hirofumi Shibata and Noriko Nishitani and Sayuri Yaohara and Naokatu Arakaki and Tomihiko Higuti and Kazuyoshi Kawazoe and Kazuo Minakuchi},
  journal={The journal of medical investigation : JMI},
  year={2012},
  volume={59 1-2},
  pages={186-91}
}
Pseudomonas aeruginosa causes both invasive (bacteremic) and chronic noninvasive infections. An increase in intestinal epithelial permeability is a characteristic of severe sepsis. Alterations in the normal barrier function of the gut mucosa may result in the translocation of microbial cells and products. On the otherhand, it has been demonstrated that statin use is associated with a lower risk of mortality from bloodstream infections. Therefore, we investigated the ability of P. aeruginosa… CONTINUE READING

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