Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients.

@article{RezaieMajd2003SimvastatinRT,
  title={Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients.},
  author={Abdolreza Rezaie-Majd and Gerald W Prager and Robert Alexander Bucek and Gerit Holger Schernthaner and Thomas Maca and H Kress and Peter Valent and Bernd R. Binder and E. Minar and Mehrdad Baghestanian},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 3},
  pages={397-403}
}
OBJECTIVE The intercellular adhesion molecule-1 (ICAM-1/CD54) and its ligand, CD11a/CD18, mediate endothelial adhesion of leukocytes and their consecutive transmigration. Anti-inflammatory effects of statins are considered to be exerted in part through inhibition of leukocyte-endothelial interactions. We investigated the in vivo effects of simvastatin treatment in hypercholesterolemic patients and the influence of various statins on expression of cellular adhesion molecules in vitro. METHODS… CONTINUE READING