Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mtDNA in Candida glabrata.

@article{Westermeyer2007SimvastatinRE,
  title={Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mtDNA in Candida glabrata.},
  author={C. Westermeyer and Ian G Macreadie},
  journal={FEMS yeast research},
  year={2007},
  volume={7 3},
  pages={
          436-41
        }
}
Statins are widely used for lowering cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. Yeasts use HMG-CoA reductase for the same enzymatic step as humans, but in yeasts the main end-product of the pathway is ergosterol rather than cholesterol. We considered that insights into the effects of statins in humans could be gained by examination of the effects of simvastatin on the petite-positive yeast Candida glabrata. Simvastatin was found to inhibit… CONTINUE READING

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imvastatin inhibits planktonic cells and biofilms f Candida and Cryptococcus species aimunda

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