Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation.

@article{Ferri2007SimvastatinRM,
  title={Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation.},
  author={Nicola Ferri and Giulia V Colombo and Corrado Ferrandi and Elaine W. Raines and Bodo Levkau and A Corsini},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 5},
  pages={1043-9}
}
OBJECTIVE Activation of collagen receptors expressed by smooth muscle cells induces matrix metalloproteinase (MMP) expression. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to interfere with integrin signaling, but their effects on collagen receptor-mediated MMP expression have not been investigated. METHODS AND RESULTS In the present study, we show that simvastatin (3 micromol/L) reduces MMP1 expression and secretion in human smooth muscle cells… CONTINUE READING

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